CagriSema
cagrilintide + semaglutide
What is in it
One manufactured injection, in trials only. It combines:
| Component | Taken alone: typical dose | How often | Status |
|---|---|---|---|
| Cagrilintide | 0.25 mg rising to 2.4 mg | Weekly | Clinical trials |
| Semaglutide | 0.25 mg rising to 2.4 mg | Weekly | FDA-approved |
Dose used in the trials
This is the only stack here with a dose from human trials. It applies to Novo Nordisk’s manufactured injection, not to research vials. In the main trial only 57% of people were on the top dose at the end.
| Each dose | Target dose: cagrilintide 2.4 mg + semaglutide 2.4 mg in one injection. The trial is reported to have stepped up from 0.25 mg of each through 0.5, 1.0 and 1.7 mg, four weeks at each step. |
|---|---|
| How often | Once a week, under the skin. |
| Weekly total | Cagrilintide 2.4 mg + semaglutide 2.4 mg at the target dose. |
| Length | 68 weeks in the trial. Participants were allowed to stay at or drop to a lower dose. |
Weekly totals are our arithmetic from each source’s own figures. Syringe units only hold for the vial and water that source assumes.
What it is promoted for
Weight loss. This is how the stack is marketed and discussed, not a finding.
What the evidence shows
This is the one combination on this page that has been tested together in large human trials. Novo Nordisk has studied cagrilintide and semaglutide as a single weekly injection in Phase 3 trials for obesity. It is not approved, and the trial product is a manufactured combination, not two research vials mixed at home.
Cautions
- Trial results apply to the manufactured product at the doses studied. They say nothing about cagrilintide bought as a research chemical.
- Semaglutide carries a boxed warning for thyroid C-cell tumors seen in rodents.
The components
Dosing and evidence for each component on its own:
Get the printable dosing chart
All 50 peptides on a few pages, as a PDF. We’ll also email you when a peptide’s approval status or dosing changes.
Reference only, not medical advice. Doses marked FDA-approved come from the US prescribing label. Doses marked Not approved are ranges reported from small studies or community use and have not been established as safe or effective in humans. Check anything here with a licensed clinician before acting on it. Read the full disclaimer.