MOTS-c + SS-31
the mitochondrial stack
What is in it
The components come in separate vials and are taken alongside each other:
| Component | Taken alone: typical dose | How often | Status |
|---|---|---|---|
| MOTS-c | 5–10 mg | 2–3 times weekly | Not approved |
| SS-31 | 40 mg | Daily | FDA-approved |
Doses reported online
No dose has been established for this combination, because it has never been through a human trial. The figures below are what named websites publish, collected in October 2026. Several of those sites sell peptides or earn commission from sellers. We report them so you can see what is being said and where it comes from. This is not a recommendation.
The sources disagree by five to ten times on both peptides, and one of them does not take the two together at all, alternating them through the year. A third source we read, a seller, withdrew its earlier protocol and now says no schedule has been established.
| Each dose | MOTS-c 1 mg. SS-31 1–2 mg for healthy people, 2–5 mg and upward for illness. |
|---|---|
| How often | MOTS-c once a day, 5 days on and 2 off. SS-31 once a day. He alternates the two instead of combining them. |
| Weekly total | MOTS-c 5 mg. SS-31 7–14 mg at the lower tier. |
| Length | MOTS-c 8–12 weeks. |
| Each dose | MOTS-c 5–10 mg, or 15 mg when taken three times a week. SS-31 5–10 mg. |
|---|---|
| How often | MOTS-c once a day or three times a week. SS-31 once a day. |
| Weekly total | MOTS-c 35–70 mg daily, or 45 mg at three times a week. SS-31 35–70 mg. |
| Length | Not stated. |
Weekly totals are our arithmetic from each source’s own figures. Syringe units only hold for the vial and water that source assumes.
What it is promoted for
Energy, endurance and “mitochondrial health”. This is how the stack is marketed and discussed, not a finding.
What the evidence shows
We found no published human trial of the two together. MOTS-c itself has no completed human efficacy trials. SS-31 (elamipretide) is FDA-approved only for Barth syndrome, a rare genetic condition, and that evidence does not extend to healthy people.
Cautions
- The idea that SS-31 should be taken first to “prepare” the mitochondria is a community claim with no trial behind it.
- Both fall under the WADA rules on non-approved substances or their relatives.
Measuring each one
Each component has its own vial and its own concentration, so each is measured separately:
Get the printable dosing chart
All 50 peptides on a few pages, as a PDF. We’ll also email you when a peptide’s approval status or dosing changes.
Reference only, not medical advice. Doses marked FDA-approved come from the US prescribing label. Doses marked Not approved are ranges reported from small studies or community use and have not been established as safe or effective in humans. Check anything here with a licensed clinician before acting on it. Read the full disclaimer.